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| Registros recuperados: 2.284 | |
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| Qi Wang. |
| 3DScape is the first plug-in which enables three-
dimensional network visualization in Cytoscape. The extra dimension is useful in accommodating, visualizing, and distinguishing larger networks with multiple crossing connections.
Special features in 3DScape include 3D layout algorithms, mapping onto 3D models and animation effects on a series of expression data. 3DScape is available at http://www.rendware.com |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6094/version/1 |
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| Martin Piskacek. |
| Recently reported, 9aaTAD transcription factors p53, VP16, MLL/ALL, E2A, HSF1, NF-IL6, NFAT1 and NF-kB interact directly with the general coactivator CBP/p300 aside from already referred TAF9. All four domains of CBP/p300 - KIX, TAZ1, TAZ2 and IBiD provide multiple interactions with 9aaTADs, e.g. p53. Annotation of predicted 9aa TAD using Pattern search ScanProsite on ExPASy and relevant experimental data are listed. |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3984/version/1 |
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| Xuri Wu; Nan Liu; Yunmian He; Yijun Chen. |
| Various ketoreductases exclusively participate in all common biological events, and they are a class of important biocatalysts for the production of chiral alcohols. While many types of ketoreductase have been extensively studied and their functions, properties and utilities have been well known, the capability of stereoselectively reducing two carbonyl groups in the same diketohexanoate ester molecule to form a dihydroxy product by a single ketoreductase has not been evidently characterized. Here we show that a unique and novel enzyme, diketoreductase, was cloned from Acinetobacter baylyi, heterogeneously expressed in _Escherichia coli_ and purified to homogeneity. The diketoreductase is up to 78% homologous to bacterial 3-hydroxyacyl coenzyme-A... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Chemistry; Microbiology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1697/version/1 |
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| Xuri Wu; Nan Liu; Yunmian He; Yijun Chen. |
| Various ketoreductases exclusively participate in all common biological events, and they are a class of important biocatalysts for the production of chiral alcohols. While many types of ketoreductase have been extensively studied and their functions, properties and utilities have been well known, the capability of stereoselectively reducing two carbonyl groups in the same diketohexanoate ester molecule to form a dihydroxy product by a single ketoreductase has not been evidently characterized. Here we show that a unique and novel enzyme, diketoreductase, was cloned from Acinetobacter baylyi, heterogeneously expressed in _Escherichia coli_ and purified to homogeneity. The diketoreductase is up to 78% homologous to bacterial 3-hydroxyacyl coenzyme-A... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Chemistry; Microbiology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/1697/version/2 |
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| Flávio Codeço Coelho; Claudia T. Codeço. |
| Mathematical models in Biology are powerful tools for the study and exploration of complex dynamics. Nevertheless, bringing theoretical results to an agreement with experimental observations involves acknowledging a great deal of uncertainty intrinsic to our theoretical representation of a real system.
Proper handling of such uncertainties, is key to the successful usage of models to predict experimental or field observations. This problem has been addressed over the years by many tools for model calibration an parameter estimation. In this article we present a general framework for uncertainty analysis and parameter estimation which is designed to handle uncertainties associated with the modeling of dynamic biological systems... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/4044/version/1 |
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| Tingting Qin; Lam Tsoi; Andrew Lawson; Jim Zheng. |
| We developed a Bayesian hierarchical model to identify gene networks based on the similarity score generated from comparing the gene ontology fingerprints of gene pairs. Genes in this network were assumed to have similar biological functions that can be indicated by their ontology fingerprints. Our results indicate that different pathways show consistent score threshold that allow us to distinguish biological relevant gene—gene connections in the network. |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3511/version/1 |
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| Andras Gelencser; Themistoklis Prodromakis; Christofer Toumazou; Tamas Roska. |
| In this paper we present a biorealistic model for the first part of the early vision processing by incorporating memristive nanodevices. The architecture of the proposed network is based on the organisation and functioning of the outer plexiform layer (OPL) in the vertebrate retina. We demonstrate that memristive devices are indeed a valuable building block for neuromorphic architectures, as their highly non-linear and adaptive response could be exploited for establishing ultra-dense networks with similar dynamics to their biological counterparts. We particularly show that hexagonal memristive grids can be employed for faithfully emulating the smoothing-effect occurring at the OPL for enhancing the dynamic range of the system. In addition, we employ a... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6664/version/1 |
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| Fucheng Zhang; Zhonghe Zhou; Xing Xu; Xiaolin Wang; Corwin Sullivan. |
| Recent coelurosaurian discoveries have greatly enriched our knowledge of the dinosaur-bird transition, but all reported taxa close to this transition are from relatively well-known coelurosaurian groups^1-3^. Here we report a new basal avialan, Epidexipteryx hui gen. et sp. nov., from the Middle-Late Jurassic of Inner Mongolia, China. This new species is characterized by an unexpected combination of characters seen in several different theropod groups, particularly the Oviraptorosauria. Phylogenetic analysis shows it to be the sister taxon to Epidendrosaurus^4,5^, forming a new clade at the base of Avialae^6^. Epidexipteryx also possesses two pairs of elongate ribbon-like tail feathers (ETFs), and its limbs lack contour feathers for flight. This finding... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2326/version/1 |
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| Donald C. Cooper. |
| “A disruptive innovation is an innovation that helps create a new market and value network, and eventually goes on to disrupt an existing market and value network (over a few years or decades), displacing an earlier technology. The term is used in business and technology literature to describe innovations that improve a product or service in ways that the market does not expect.” -Wikipedia
On April 3rd, 2012 Nature Precedings, Nature Publishing Group’s experiment in free pre-print publishing was shut down and no longer accepts submissions. According to the Nature Precedings website it was created in 2007 as “a place for researchers to share documents, including presentations, posters, white... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Neuroscience; Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7151/version/1 |
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| Nicholas J. Gales; Phillip J. Clapham; C. Scott Baker. |
| During the austral summer of 2007/08, hunting of Southern Hemisphere (SH) humpback whales will recommence after almost half a century of protection. The stated rationale for this hunt, by the Government of Japan (GoJ), is to gather important scientific information for use in management. If the scientific need were defensible, and the proponents had accommodated reasonable conservation concerns, then criticisms of the hunt would be limited to philosophical issues. This is not the case. The program’s research objectives are unlikely to be achieved by lethal methods and do not address the principal research needs for SH humpback whales identified by the International Whaling Commission (IWC). |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1313/version/1 |
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| Yukio Nishimura; Yosuke Morichika; Tadashi Isa. |
| Recent studies in monkeys showed that when the direct cortico-motoneuronal connection was transected at mid-cervical segments, remaining, indirect cortico-motoneuronal pathways compensated for finger dexterity within one to three months. To elucidate the changes in dynamic properties of neural circuits during the recovery, we investigated the cortico-muscular and inter-muscular couplings of activities throughout the recovery course. Activities of antagonist muscle pairs showed co-activation during the second postoperative week, and oscillated coherently at frequencies of 30-46 Hz (gamma-band) by one month postoperatively. Such gamma-band inter-muscular coherence was not observed preoperatively, but became prominent and distributed widely over proximal and... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1937/version/1 |
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| Kshitish K. Acharya; Greta Kasliwal; Haritha Haridas. |
| With increasing number of bibliographic software, scientists and health professionals either make a subjective choice of tool(s) that could suit their needs or face a challenge of analyzing multiple features of a plethora of search programs. There is an urgent need for a thorough comparative analysis of the available bio-literature scanning tools, from the user’s perspective. We report results of the first time semi-quantitative comparison of 21 programs, which can search published (partial or full text) documents in life science areas. The observations can assist life science researchers and medical professionals to make an informed selection among the programs, depending on their search objectives. 
Some of the important... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2101/version/1 |
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| Sierra Rayne; Kaya Forest. |
| New experimental data is available in the literature regarding the octanol-water distribution behavior of representative straight chain perfluoroalkyl carboxylate (PFCA) and sulfonate (PFSA) congeners. The current study provides the first investigation into the predictive ability of various software programs for estimating the corresponding octanol-water partitioning (log P) and distribution (log D) constants of PFCAs and PFSAs. Wide predictive variation was found within and between the various methods. Several programs were able to accurately estimate the log P/D fragmental contributions of a -CF~2~- group for PFCAs, as well as the associated Gibbs free energies for partitioning into octanol from water due to the hydrophobic character of the... |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Earth & Environment. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3282/version/1 |
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| Sierra Rayne; Kaya Forest. |
| New experimental data is available in the literature regarding the octanol-water distribution behavior of representative straight chain perfluoroalkyl carboxylate (PFCA) and sulfonate (PFSA) congeners. The current study provides the first investigation into the predictive ability of various software programs for estimating the corresponding octanol-water partitioning (log P) and distribution (log D) constants of PFCAs and PFSAs. Wide predictive variation was found within and between the various methods. Several programs were able to accurately estimate the log P/D fragmental contributions of a -CF~2~- group for PFCAs, as well as the associated Gibbs free energies for partitioning into octanol from water due to the hydrophobic character of the... |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Earth & Environment. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3282/version/2 |
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| John C. Rodda; Max A. Little; Harvey J. E. Rodda; Patrick E. McSharry. |
| During the 1960s, a study was made of the magnitude, frequency and distribution of intense rainfall over the UK, employing data from more than 120 daily-read rain gauges covering the period 1911 to 1960. Using the same methodology, that study was recently updated utilizing data for the period 1961 to 2006 for the same gauges, or from those nearby. This paper describes the techniques applied to ensure consistency of data and statistical modelling. It presents a comparison of patterns of extreme rainfalls for the two periods and discusses the changes that have taken place. Most noticeably, increases up to 20% have occurred in the north west of the country and in parts of East Anglia. There have also been changes in other areas, including decreases of the... |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3847/version/1 |
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| Shaheed SM; Rohit JP; Madhan R; Selvakumar K. |
| Ethanol derived from non-edible biomass is renewable and a clean source of energy. It is independent of the food industry and it is economically feasible. The first generation biofuel or bioethanol is still not a very convenient source of energy as it prominently depends on the availability of grains. The main objective of this work is to develop an industrious efficient process to produce ethanol from lignocellulosic biomasses like wood and leaf in a lab scale. Two processes were compared. The first process involved an alkaline pre-treatment of the powdered biomass followed by dilute acid hydrolysis. The second process involved an alkaline treatment followed by direct hydrolysis of the biomass by use of a fungal species obtained from rotting wood.... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6579/version/1 |
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| Mark Conyers. |
| Standard texts dutifully list 16 essential elements for plant growth, yet the literature indicates that the boundary between essential and nonessential nutrients for plants is not always clear. When animals and 'lower' organisms are considered, the team of 16 is considerably expanded and the notion of essentiality is blurred. Why are some elements more important than others to plants and to organisms in general? Here I propose three criteria by which elements might have been selected in the development of organisms: low atomic weight, at least modest abundance, and ease of assembly into complex structures. Assembly of the structural elements C, N, S, P, and O is based on valency and ionic potential. The selection of monovalent elements... |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment; Evolutionary Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3223/version/1 |
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| Tomohiko Konno. |
| Natural selection is often regarded as a result of severe competition. Defect seems beneficial for a single individual in many cases.However, cooperation is observed in many levels of biological systems ranging from single cells to animals, including human society. We have yet known that in unstructured populations, evolution favors defectors over cooperators. On the other hand, there have been much interest on evolutionary games^1,2^ on structured population and on graphs^3-16^. Structures of biological systems and societies of animals can be taken as networks. They discover that network structures determine results of the games. Together with the recent interest of complex networks^17,18^, many researchers investigate real network structures. Recently... |
| Tipo: Manuscript |
Palavras-chave: Evolutionary Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3028/version/1 |
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| Registros recuperados: 2.284 | |
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